5FP3

Cell penetrant inhibitors of the JMJD2 (KDM4) and JARID1 (KDM5) families of histone lysine demethylases

Summary for 5FP3

Entry DOI	10.2210/pdb5fp3/pdb
Related	5FP4 5FP7 5FP8 5FP9 5FPA 5FPB
Descriptor	HUMAN LYSINE-SPECIFIC DEMETHYLASE 6B, JMJD3, 3-(4-phenylbutanoylamino)pyridine-4-carboxylic acid, ZINC ION, ... (7 entities in total)
Functional Keywords	oxidoreductase, inhibitor, jmjd3, kdm6b, jumonji
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	2
Total formula weight	117667.78
Authors	Chung, C. (deposition date: 2015-11-27, release date: 2016-01-27, Last modification date: 2019-10-30)
Primary citation	Westaway, S.M.,Preston, A.G.S.,Barker, M.D.,Brown, F.,Brown, J.A.,Campbell, M.,Chung, C.,Diallo, H.,Douault, C.,Drewes, G.,Eagle, R.,Gordon, L.,Haslam, C.,Hayhow, T.G.,Humphreys, P.G.,Joberty, G.,Katso, R.,Kruidenier, L.,Leveridge, M.,Liddle, J.,Mosley, J.,Muelbaier, M.,Randle, R.,Rioja, I.,Rueger, A.,Seal, G.A.,Sheppard, R.J.,Singh, O.,Taylor, J.,Thomas, P.,Thomson, D.,Wilson, D.M.,Lee, K.,Prinjha, R.K. Cell Penetrant Inhibitors of the Kdm4 and Kdm5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-Pyridine Carboxylate Derivatives. J.Med.Chem., 59:1357-, 2016 Cited by PubMed: 26771107 DOI: 10.1021/ACS.JMEDCHEM.5B01537 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation