5FP3
Cell penetrant inhibitors of the JMJD2 (KDM4) and JARID1 (KDM5) families of histone lysine demethylases
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | HUMAN LYSINE-SPECIFIC DEMETHYLASE 6B, JMJD3 | polymer | 510 | 58050.3 | 2 | UniProt (O15054) Pfam (PF02373) Pfam (PF21322) Pfam (PF21326) | HOMO SAPIENS (HUMAN) | JMJC DOMAIN-CONTAINING PROTEIN 3, JUMONJI DOMAIN-CONTAINING PROTEIN 3, LYSINE DEMETHYLASE 6B, JMJD3 |
| 2 | C, J (A, B) | 3-(4-phenylbutanoylamino)pyridine-4-carboxylic acid | non-polymer | 284.3 | 2 | Chemie (YC8) | |||
| 3 | D, K (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | E, H, L, O (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 5 | F, G, M, N (A, B) | BICINE | non-polymer | 163.2 | 4 | Chemie (BCN) | |||
| 6 | I, P (A, B) | COBALT (II) ION | non-polymer | 58.9 | 2 | Chemie (CO) | |||
| 7 | Q, R (A, B) | water | water | 18.0 | 835 | Chemie (HOH) |
Sequence modifications
A, B: 1141 - 1643 (UniProt: O15054)
| PDB | External Database | Details |
|---|---|---|
| Met 1140 | - | expression tag |
| His 1644 | - | expression tag |
| His 1645 | - | expression tag |
| His 1646 | - | expression tag |
| His 1647 | - | expression tag |
| His 1648 | - | expression tag |
| His 1649 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 116100.6 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1567.2 | |
| All* | Total formula weight | 117667.8 |
