5FPB

Crystal structure of human KDM4D in complex with 2-1H-pyrazol-4-yloxy- 3H,4H-pyrido-3,4-d-pyrimidin-4-one

Summary for 5FPB

Entry DOI	10.2210/pdb5fpb/pdb
Related	5FP3 5FP4 5FP7 5FP8 5FP9 5FPA
Descriptor	LYSINE-SPECIFIC DEMETHYLASE 4D, ZINC ION, COBALT (II) ION, ... (6 entities in total)
Functional Keywords	oxidoreductase, inhibitor, lysine specific histone demethylase, jmjd2d, kdm4d, jumonji
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Nucleus : Q6B0I6
Total number of polymer chains	1
Total formula weight	39560.61
Authors	Chung, C. (deposition date: 2015-11-27, release date: 2016-01-27, Last modification date: 2016-03-09)
Primary citation	Westaway, S.M.,Preston, A.G.S.,Barker, M.D.,Brown, F.,Brown, J.A.,Campbell, M.,Chung, C.,Diallo, H.,Douault, C.,Drewes, G.,Eagle, R.,Gordon, L.,Haslam, C.,Hayhow, T.G.,Humphreys, P.G.,Joberty, G.,Katso, R.,Kruidenier, L.,Leveridge, M.,Liddle, J.,Mosley, J.,Muelbaier, M.,Randle, R.,Rioja, I.,Rueger, A.,Seal, G.A.,Sheppard, R.J.,Singh, O.,Taylor, J.,Thomas, P.,Thomson, D.,Wilson, D.M.,Lee, K.,Prinjha, R.K. Cell Penetrant Inhibitors of the Kdm4 and Kdm5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-Pyridine Carboxylate Derivatives. J.Med.Chem., 59:1357-, 2016 Cited by PubMed: 26771107 DOI: 10.1021/ACS.JMEDCHEM.5B01537 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.91 Å)

Structure validation