5FPB

Crystal structure of human KDM4D in complex with 2-1H-pyrazol-4-yloxy- 3H,4H-pyrido-3,4-d-pyrimidin-4-one

Summary for 5FPB

Related5FP3 5FP4 5FP7 5FP8 5FP9 5FPA
DescriptorLYSINE-SPECIFIC DEMETHYLASE 4D, ZINC ION, COBALT (II) ION, ... (6 entities in total)
Functional Keywordsoxidoreductase, inhibitor, lysine specific histone demethylase, jmjd2d, kdm4d, jumonji
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationNucleus  Q6B0I6
Total number of polymer chains1
Total molecular weight39560.61
Authors
Chung, C. (deposition date: 2015-11-27, release date: 2016-01-27, Last modification date: 2016-03-09)
Primary citation
Westaway, S.M.,Preston, A.G.S.,Barker, M.D.,Brown, F.,Brown, J.A.,Campbell, M.,Chung, C.,Diallo, H.,Douault, C.,Drewes, G.,Eagle, R.,Gordon, L.,Haslam, C.,Hayhow, T.G.,Humphreys, P.G.,Joberty, G.,Katso, R.,Kruidenier, L.,Leveridge, M.,Liddle, J.,Mosley, J.,Muelbaier, M.,Randle, R.,Rioja, I.,Rueger, A.,Seal, G.A.,Sheppard, R.J.,Singh, O.,Taylor, J.,Thomas, P.,Thomson, D.,Wilson, D.M.,Lee, K.,Prinjha, R.K.
Cell Penetrant Inhibitors of the Kdm4 and Kdm5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-Pyridine Carboxylate Derivatives.
J.Med.Chem., 59:1357-, 2016
PubMed: 26771107 (PDB entries with the same primary citation)
DOI: 10.1021/ACS.JMEDCHEM.5B01537
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.91 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.213100.4%7.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 5fpb
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Molmil generated image of 5fpb
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Molmil generated image of 5fpb
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