5FP7

Crystal structure of human KDM4D in complex with 3-4-methylthiophen-2- yl methylaminopyridine-4-carboxylic acid

Summary for 5FP7

Entry DOI	10.2210/pdb5fp7/pdb
Related	5FP3 5FP4 5FP8 5FP9 5FPA 5FPB
Descriptor	LYSINE-SPECIFIC DEMETHYLASE 4D, ZINC ION, FE (II) ION, ... (7 entities in total)
Functional Keywords	inhibitor, lysine specific histone demethylase, jmjd2d, kdm4d, jumonji
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	39888.92
Authors	Chung, C. (deposition date: 2015-11-27, release date: 2016-11-09, Last modification date: 2019-01-16)
Primary citation	Westaway, S.M.,Preston, A.G.,Barker, M.D.,Brown, F.,Brown, J.A.,Campbell, M.,Chung, C.W.,Drewes, G.,Eagle, R.,Garton, N.,Gordon, L.,Haslam, C.,Hayhow, T.G.,Humphreys, P.G.,Joberty, G.,Katso, R.,Kruidenier, L.,Leveridge, M.,Pemberton, M.,Rioja, I.,Seal, G.A.,Shipley, T.,Singh, O.,Suckling, C.J.,Taylor, J.,Thomas, P.,Wilson, D.M.,Lee, K.,Prinjha, R.K. Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives. J. Med. Chem., 59:1370-1387, 2016 Cited by PubMed: 26771203 DOI: 10.1021/acs.jmedchem.5b01538 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation