5FP7
Crystal structure of human KDM4D in complex with 3-4-methylthiophen-2- yl methylaminopyridine-4-carboxylic acid
Summary for 5FP7
| Entry DOI | 10.2210/pdb5fp7/pdb |
| Related | 5FP3 5FP4 5FP8 5FP9 5FPA 5FPB |
| Descriptor | LYSINE-SPECIFIC DEMETHYLASE 4D, ZINC ION, FE (II) ION, ... (7 entities in total) |
| Functional Keywords | inhibitor, lysine specific histone demethylase, jmjd2d, kdm4d, jumonji |
| Biological source | HOMO SAPIENS (HUMAN) |
| Total number of polymer chains | 1 |
| Total formula weight | 39888.92 |
| Authors | Chung, C. (deposition date: 2015-11-27, release date: 2016-11-09, Last modification date: 2024-05-08) |
| Primary citation | Westaway, S.M.,Preston, A.G.,Barker, M.D.,Brown, F.,Brown, J.A.,Campbell, M.,Chung, C.W.,Drewes, G.,Eagle, R.,Garton, N.,Gordon, L.,Haslam, C.,Hayhow, T.G.,Humphreys, P.G.,Joberty, G.,Katso, R.,Kruidenier, L.,Leveridge, M.,Pemberton, M.,Rioja, I.,Seal, G.A.,Shipley, T.,Singh, O.,Suckling, C.J.,Taylor, J.,Thomas, P.,Wilson, D.M.,Lee, K.,Prinjha, R.K. Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives. J. Med. Chem., 59:1370-1387, 2016 Cited by PubMed Abstract: Following the discovery of cell penetrant pyridine-4-carboxylate inhibitors of the KDM4 (JMJD2) and KDM5 (JARID1) families of histone lysine demethylases (e.g., 1), further optimization led to the identification of non-carboxylate inhibitors derived from pyrido[3,4-d]pyrimidin-4(3H)-one. A number of exemplars such as compound 41 possess interesting activity profiles in KDM4C and KDM5C biochemical and target-specific, cellular mechanistic assays. PubMed: 26771203DOI: 10.1021/acs.jmedchem.5b01538 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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