5FP7
Crystal structure of human KDM4D in complex with 3-4-methylthiophen-2- yl methylaminopyridine-4-carboxylic acid
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 350 |
| Chain | Residue |
| A | CYS238 |
| A | HIS244 |
| A | CYS310 |
| A | CYS312 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FE2 A 360 |
| Chain | Residue |
| A | HOH2317 |
| A | HIS192 |
| A | GLU194 |
| A | HIS280 |
| A | YC81344 |
| A | HOH2312 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 1341 |
| Chain | Residue |
| A | PHE21 |
| A | HIS22 |
| A | GLU27 |
| A | TYR34 |
| A | TYR37 |
| A | HOH2036 |
| A | HOH2044 |
| A | HOH2452 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 1342 |
| Chain | Residue |
| A | PHE31 |
| A | LYS150 |
| A | TRP152 |
| A | ASN153 |
| A | HOH2062 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 1343 |
| Chain | Residue |
| A | PHE118 |
| A | ARG263 |
| A | ILE264 |
| A | THR265 |
| A | HOH2398 |
| A | HOH2453 |
| site_id | AC6 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE YC8 A 1344 |
| Chain | Residue |
| A | LEU75 |
| A | HIS90 |
| A | TYR136 |
| A | ASP139 |
| A | PHE189 |
| A | HIS192 |
| A | ASN202 |
| A | LYS210 |
| A | TRP212 |
| A | LYS245 |
| A | HIS280 |
| A | FE2360 |
| A | HOH2165 |
| A | HOH2312 |
| A | HOH2317 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1345 |
| Chain | Residue |
| A | PRO113 |
| A | LYS124 |
| A | ASN128 |
| A | TRP185 |
| A | LYS186 |
| A | HOH2247 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1346 |
| Chain | Residue |
| A | ARG60 |
| A | GLU61 |
| A | THR62 |
| A | ASN65 |
| A | HOH2133 |
| A | HOH2135 |
| A | HOH2146 |
| A | HOH2294 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1347 |
| Chain | Residue |
| A | ARG123 |
| A | LYS124 |
| A | LYS127 |
| A | ASN128 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1348 |
| Chain | Residue |
| A | ARG102 |
| A | HIS103 |
| A | ASN106 |
| A | HOH2201 |
| A | HOH2455 |
| A | HOH2456 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1349 |
| Chain | Residue |
| A | TYR179 |
| A | TYR181 |
| A | ALA292 |
| A | ILE293 |
| A | ASN294 |
| A | HOH2454 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1350 |
| Chain | Residue |
| A | GLN116 |
| A | GLN116 |
| A | ASN117 |
| A | ASN117 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1351 |
| Chain | Residue |
| A | ASP302 |
| A | TYR303 |
| A | MET306 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 42 |
| Details | Domain: {"description":"JmjN","evidences":[{"source":"PROSITE-ProRule","id":"PRU00537","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 166 |
| Details | Domain: {"description":"JmjC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"B2RXH2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26741168","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"5F5A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F5C","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"PolyADP-ribosyl glutamic acid","evidences":[{"source":"PubMed","id":"23102699","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
