5E4O
Human transthyretin (TTR) complexed with (Z)-((3,4-Dichloro-phenyl)-methyleneaminooxy)-acetic acid
Summary for 5E4O
Entry DOI | 10.2210/pdb5e4o/pdb |
Related | 4TQ8 4TQH 4TQI 4TQP 5E23 5E4A |
Descriptor | Transthyretin, ({(Z)-[(3,4-dichlorophenyl)(phenyl)methylidene]amino}oxy)acetic acid (3 entities in total) |
Functional Keywords | fluorenone based fibrillogenesis inhibitor, transport protein |
Biological source | Homo sapiens (Human) |
Cellular location | Secreted: P02766 |
Total number of polymer chains | 2 |
Total formula weight | 26313.11 |
Authors | Ciccone, L.,Savko, M.,Nencetti, S.,Rossello, A.,Orlandini, E.,Stura, E.A. (deposition date: 2015-10-06, release date: 2016-03-23, Last modification date: 2024-05-08) |
Primary citation | Ciccone, L.,Nencetti, S.,Rossello, A.,Stura, E.A.,Orlandini, E. Synthesis and structural analysis of halogen substituted fibril formation inhibitors of Human Transthyretin (TTR). J Enzyme Inhib Med Chem, 31:40-51, 2016 Cited by PubMed: 27067161DOI: 10.3109/14756366.2016.1167048 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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