4ZZ1

HUMAN GAR TRANSFORMYLASE IN COMPLEX WITH GAR AND (S)-2-({4-[3-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-6-YL)-PROPYL]-THIOPHENE-2-CARBONYL}-AMINO)-PENTANEDIOIC ACID

4ZZ1 の概要

• エントリーDOI: 10.2210/pdb4zz1/pdb
• 関連するPDBエントリー: 1MEJ 1MEN 1MEO 1NJS 1RBM 1RBQ 1RBY 1RBZ 1RC0 1RC1 1ZLX 1ZLY 4EW2 4EW3 4ZYT 4ZYU 4ZYV 4ZYW 4ZYX 4ZYY 4ZYZ 4ZZ0 4ZZ2 4ZZ3
• 分子名称: Trifunctional purine biosynthetic protein adenosine-3, GLYCINAMIDE RIBONUCLEOTIDE, (S)-2-({4-[3-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-propyl]-thiophene-2-carbonyl}-amino)-pentanedioic acid, ... (4 entities in total)
• 機能のキーワード: gar transformylase, antifolate, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 23541.76

構造登録者

Deis, S.M.,Dann III, C.E. (登録日: 2015-05-22, 公開日: 2015-12-16, 最終更新日: 2023-09-27)

• 主引用文献: Wang, L.,Wallace, A.,Raghavan, S.,Deis, S.M.,Wilson, M.R.,Yang, S.,Polin, L.,White, K.,Kushner, J.,Orr, S.,George, C.,O'Connor, C.,Hou, Z.,Mitchell-Ryan, S.,Dann, C.E.,Matherly, L.H.,Gangjee, A.; 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor alpha and the Proton-Coupled Folate Transporter in Human Tumors.; J.Med.Chem., 58:6938-6959, 2015; PubMed: 26317331; DOI: 10.1021/acs.jmedchem.5b00801

実験手法

X-RAY DIFFRACTION (1.351 Å)