4ZYW

Human GAR transformylase in complex with GAR and N-({5-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)propyl]thiophen-2-yl}carbonyl)-L-glutamic acid (AGF94)

4ZYW の概要

• エントリーDOI: 10.2210/pdb4zyw/pdb
• 関連するPDBエントリー: 1MEJ 1MEN 1MEO 1NJS 1RBM 1RBQ 1RBY 1RBZ 1RC0 1RC1 1ZLX 1ZLY 4EW2 4EW3 4ZYT 4ZYU 4ZYV 4ZYX 4ZYY 4ZYZ 4ZZ0 4ZZ1 4ZZ2 4ZZ3
• 分子名称: Trifunctional purine biosynthetic protein adenosine-3, GLYCINAMIDE RIBONUCLEOTIDE, N-({5-[3-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-6-yl)propyl]thiophen-2-yl}carbonyl)-L-glutamic acid, ... (4 entities in total)
• 機能のキーワード: gar transformylase, antifolate, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 23541.76

構造登録者

Deis, S.M.,Dann III, C.E. (登録日: 2015-05-22, 公開日: 2016-04-20, 最終更新日: 2023-09-27)

• 主引用文献: Deis, S.M.,Doshi, A.,Hou, Z.,Matherly, L.H.,Gangjee, A.,Dann, C.E.; Structural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase.; Biochemistry, 55:4574-4582, 2016; PubMed: 27439469; DOI: 10.1021/acs.biochem.6b00412

実験手法

X-RAY DIFFRACTION (2.05 Å)