4XBE
Crystal structure of human 4E10 Fab in complex with its peptide epitope on HIV-1 gp41: crystals cryoprotected with sphingomyelin (02:0 SM (d18:1/2:0)).
Summary for 4XBE
Entry DOI | 10.2210/pdb4xbe/pdb |
Related | 2FX7 4XAW 4XBG 4XBP 4XC1 4XC3 4XCC 4XCE 4XCF 4XCN 4XCY |
Descriptor | 4E10 FAB LIGHT CHAIN, 4E10 Fab heavy chain, PEPTIDE FRAGMENT OF HIV GLYCOPROTEIN (GP41) including the region 671-683 of the MPER, ... (5 entities in total) |
Functional Keywords | hiv-1 gp41 mper, 4e10 fab, membrane lipid, immune system |
Biological source | Homo sapiens More |
Total number of polymer chains | 3 |
Total formula weight | 49634.50 |
Authors | Irimia, A.,Stanfield, R.L.,Wilson, I.A. (deposition date: 2014-12-16, release date: 2016-02-03, Last modification date: 2023-09-27) |
Primary citation | Irimia, A.,Sarkar, A.,Stanfield, R.L.,Wilson, I.A. Crystallographic Identification of Lipid as an Integral Component of the Epitope of HIV Broadly Neutralizing Antibody 4E10. Immunity, 44:21-31, 2016 Cited by PubMed: 26777395DOI: 10.1016/j.immuni.2015.12.001 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.756 Å) |
Structure validation
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