4XBE

Crystal structure of human 4E10 Fab in complex with its peptide epitope on HIV-1 gp41: crystals cryoprotected with sphingomyelin (02:0 SM (d18:1/2:0)).

4XBE の概要

• エントリーDOI: 10.2210/pdb4xbe/pdb
• 関連するPDBエントリー: 2FX7 4XAW 4XBG 4XBP 4XC1 4XC3 4XCC 4XCE 4XCF 4XCN 4XCY
• 分子名称: 4E10 FAB LIGHT CHAIN, 4E10 Fab heavy chain, PEPTIDE FRAGMENT OF HIV GLYCOPROTEIN (GP41) including the region 671-683 of the MPER, ... (5 entities in total)
• 機能のキーワード: hiv-1 gp41 mper, 4e10 fab, membrane lipid, immune system
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 49634.50

構造登録者

Irimia, A.,Stanfield, R.L.,Wilson, I.A. (登録日: 2014-12-16, 公開日: 2016-02-03, 最終更新日: 2023-09-27)

• 主引用文献: Irimia, A.,Sarkar, A.,Stanfield, R.L.,Wilson, I.A.; Crystallographic Identification of Lipid as an Integral Component of the Epitope of HIV Broadly Neutralizing Antibody 4E10.; Immunity, 44:21-31, 2016; PubMed: 26777395; DOI: 10.1016/j.immuni.2015.12.001

実験手法

X-RAY DIFFRACTION (1.756 Å)