4RUI

Crystal structure of a cytochrome P450 2A6 in complex with a monoterpene - sabinene.

Summary for 4RUI

Entry DOI	10.2210/pdb4rui/pdb
Related	1Z10 1Z11 2FDU 2FDV 2FDW 2FDY 3EBS 3T3Q 3T3R 4EJJ
Descriptor	Cytochrome P450 2A6, PROTOPORPHYRIN IX CONTAINING FE, Sabinene, ... (4 entities in total)
Functional Keywords	p450, cytochrome p450 2a6, monooxygenase, oxidoreductase, membrane protein, cyp2a6, endoplasmic reticulum, heme, iron, membrane, metal binding, microsome
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein: P11509
Total number of polymer chains	6
Total formula weight	332546.15
Authors	Shah, M.B.,Stout, C.D.,Halpert, J.R. (deposition date: 2014-11-19, release date: 2015-01-28, Last modification date: 2024-05-22)
Primary citation	Shah, M.B.,Wilderman, P.R.,Liu, J.,Jang, H.H.,Zhang, Q.,Stout, C.D.,Halpert, J.R. Structural and Biophysical Characterization of Human Cytochromes P450 2B6 and 2A6 Bound to Volatile Hydrocarbons: Analysis and Comparison. Mol.Pharmacol., 87:649-659, 2015 Cited by PubMed: 25585967 DOI: 10.1124/mol.114.097014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.61 Å)

Structure validation