4I3H

A three-gate structure of topoisomerase IV from Streptococcus pneumoniae

Summary for 4I3H

• Entry DOI: 10.2210/pdb4i3h/pdb
• Related: 1EI1 2NOV 3FOE 3FOF 3K9F 3KSA 3KSB 3LTN 3RAD 3RAE 3RAF 4GFH
• Descriptor: DNA (5'-D(*CP*AP*AP*AP*GP*GP*CP*GP*GP*TP*AP*AP*TP*AP*CP*GP*GP*TP*TP*AP*TP*CP*CP*AP*CP*AP*GP*AP*AP*TP*CP*AP*GP*G)-3'), DNA (5'-D(*CP*CP*TP*GP*AP*TP*TP*CP*TP*GP*TP*GP*GP*AP*TP*AP*AP*CP*CP*GP*TP*AP*TP*TP*AP*CP*CP*GP*CP*CP*TP*TP*TP*G)-3'), Topoisomerase IV subunit B, DNA topoisomerase 4 subunit A chimera, ... (5 entities in total)
• Functional Keywords: dna unwinding, supercoiling, isomerase-dna complex, isomerase/dna
• Biological source: Streptococcus pneumoniae; More
• Cellular location: Cell membrane ; Peripheral membrane protein : D6ZLV0
• Total number of polymer chains: 6
• Total formula weight: 298555.59

Authors

Laponogov, I.,Veselkov, D.A.,Pan, X.-S.,Crevel, I.,Fisher, L.M.,Sanderson, M.R. (deposition date: 2012-11-26, release date: 2013-08-28, Last modification date: 2023-09-20)

• Primary citation: Laponogov, I.,Veselkov, D.A.,Crevel, I.M.,Pan, X.S.,Fisher, L.M.,Sanderson, M.R.; Structure of an 'open' clamp type II topoisomerase-DNA complex provides a mechanism for DNA capture and transport.; Nucleic Acids Res., 41:9911-9923, 2013; PubMed: 23965305; DOI: 10.1093/nar/gkt749

Experimental method

X-RAY DIFFRACTION (3.7 Å)