Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003916 | molecular_function | DNA topoisomerase activity |
| A | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005694 | cellular_component | chromosome |
| A | 0006259 | biological_process | DNA metabolic process |
| A | 0006265 | biological_process | DNA topological change |
| A | 0007059 | biological_process | chromosome segregation |
| A | 0034335 | molecular_function | DNA negative supercoiling activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003916 | molecular_function | DNA topoisomerase activity |
| B | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005694 | cellular_component | chromosome |
| B | 0006259 | biological_process | DNA metabolic process |
| B | 0006265 | biological_process | DNA topological change |
| B | 0007059 | biological_process | chromosome segregation |
| B | 0034335 | molecular_function | DNA negative supercoiling activity |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 1700 |
| Chain | Residue |
| A | PHE1316 |
| A | LYS1317 |
| A | THR1319 |
| A | GLN1322 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG B 1700 |
| Chain | Residue |
| B | PHE1316 |
| B | THR1319 |
| B | GLN1322 |
Functional Information from PROSITE/UniProt
| site_id | PS00177 |
| Number of Residues | 9 |
| Details | TOPOISOMERASE_II DNA topoisomerase II signature. LVEGDSAGG |
| Chain | Residue | Details |
| A | LEU431-GLY439 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | TYR11 | |
| B | LYS344 | |
| A | ASN51 | |
| A | ASP78 | |
| A | GLY118 | |
| A | LYS344 | |
| B | TYR11 | |
| B | ASN51 | |
| B | ASP78 | |
| B | GLY118 | |
| Chain | Residue | Details |
| A | GLU433 | |
| A | ASP506 | |
| A | ASP508 | |
| B | GLU433 | |
| B | ASP506 | |
| B | ASP508 | |
| Chain | Residue | Details |
| A | LYS458 | |
| A | ASN461 | |
| A | HIS513 | |
| A | ARG629 | |
| B | LYS458 | |
| B | ASN461 | |
| B | HIS513 | |
| B | ARG629 | |
| Chain | Residue | Details |
| A | TYR1118 | |
| B | TYR1118 | |
| site_id | SWS_FT_FI5 |
| Number of Residues | 10 |
| Details | SITE: Interaction with DNA |
| Chain | Residue | Details |
| A | LYS1038 | |
| B | LYS1093 | |
| A | HIS1074 | |
| A | HIS1076 | |
| A | ARG1087 | |
| A | LYS1093 | |
| B | LYS1038 | |
| B | HIS1074 | |
| B | HIS1076 | |
| B | ARG1087 | |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | SITE: Transition state stabilizer |
| Chain | Residue | Details |
| A | ARG1117 | |
| B | ARG1117 | |
