4I3H

A three-gate structure of topoisomerase IV from Streptococcus pneumoniae

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003916	molecular_function	DNA topoisomerase activity
A	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
A	0005524	molecular_function	ATP binding
A	0005694	cellular_component	chromosome
A	0006259	biological_process	DNA metabolic process
A	0006265	biological_process	DNA topological change
A	0007059	biological_process	chromosome segregation
A	0046872	molecular_function	metal ion binding
B	0003677	molecular_function	DNA binding
B	0003916	molecular_function	DNA topoisomerase activity
B	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
B	0005524	molecular_function	ATP binding
B	0005694	cellular_component	chromosome
B	0006259	biological_process	DNA metabolic process
B	0006265	biological_process	DNA topological change
B	0007059	biological_process	chromosome segregation
B	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 1700

Chain	Residue
A	PHE1316
A	LYS1317
A	THR1319
A	GLN1322

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site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG B 1700

Chain	Residue
B	PHE1316
B	THR1319
B	GLN1322

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Functional Information from PROSITE/UniProt

site_id	PS00177
Number of Residues	9
Details	TOPOISOMERASE_II DNA topoisomerase II signature. LVEGDSAGG

Chain	Residue	Details
A	LEU431-GLY439

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00939

Chain	Residue	Details
A	TYR11
B	LYS344
A	ASN51
A	ASP78
A	GLY118
A	LYS344
B	TYR11
B	ASN51
B	ASP78
B	GLY118

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00939, ECO:0000269|PubMed:20596531

Chain	Residue	Details
A	GLU433
A	ASP506
A	ASP508
B	GLU433
B	ASP506
B	ASP508

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site_id	SWS_FT_FI3
Number of Residues	8
Details	SITE: Interaction with DNA => ECO:0000255|HAMAP-Rule:MF_00939

Chain	Residue	Details
A	LYS458
A	ASN461
A	HIS513
A	ARG629
B	LYS458
B	ASN461
B	HIS513
B	ARG629

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	ACT_SITE: O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|HAMAP-Rule:MF_00937, ECO:0000269|PubMed:20596531

Chain	Residue	Details
A	TYR1118
B	TYR1118

---

site_id	SWS_FT_FI5
Number of Residues	10
Details	SITE: Interaction with DNA

Chain	Residue	Details
A	LYS1038
B	LYS1093
A	HIS1074
A	HIS1076
A	ARG1087
A	LYS1093
B	LYS1038
B	HIS1074
B	HIS1076
B	ARG1087

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	SITE: Transition state stabilizer

Chain	Residue	Details
A	ARG1117
B	ARG1117

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