Structure of Human Microsomal Cytochrome P450 (CYP) 2C19

Summary for 4GQS

Related1R9O 1OG2 1OG5 1PQ2 2NNJ 2NNI
DescriptorCytochrome P450 2C19, PROTOPORPHYRIN IX CONTAINING FE, (4-hydroxy-3,5-dimethylphenyl)(2-methyl-1-benzofuran-3-yl)methanone, ... (5 entities in total)
Functional Keywordsmonooxygenase, drug metabolizing enzyme, oxidoreductase, heme protein
Biological sourceHomo sapiens (human)
Cellular locationEndoplasmic reticulum membrane; Peripheral membrane protein P33261
Total number of polymer chains4
Total molecular weight222187.5
Reynald, R.L.,Sansen, S.,Stout, C.D.,Johnson, E.F. (deposition date: 2012-08-23, release date: 2012-11-14, Last modification date: 2013-01-16)
Primary citation
Reynald, R.L.,Sansen, S.,Stout, C.D.,Johnson, E.F.
Structural Characterization of Human Cytochrome P450 2C19: ACTIVE SITE DIFFERENCES BETWEEN P450s 2C8, 2C9, AND 2C19.
J.Biol.Chem., 287:44581-44591, 2012
PubMed: 23118231 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M112.424895
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.291230.7%1.2%2.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-08-05