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4GQS

Structure of Human Microsomal Cytochrome P450 (CYP) 2C19

Summary for 4GQS
Entry DOI10.2210/pdb4gqs/pdb
Related1OG2 1OG5 1PQ2 1R9O 2NNI 2NNJ
DescriptorCytochrome P450 2C19, PROTOPORPHYRIN IX CONTAINING FE, (4-hydroxy-3,5-dimethylphenyl)(2-methyl-1-benzofuran-3-yl)methanone, ... (5 entities in total)
Functional Keywordsmonooxygenase, drug metabolizing enzyme, oxidoreductase, heme protein
Biological sourceHomo sapiens (human)
Cellular locationEndoplasmic reticulum membrane; Peripheral membrane protein: P33261
Total number of polymer chains4
Total formula weight222187.50
Authors
Reynald, R.L.,Sansen, S.,Stout, C.D.,Johnson, E.F. (deposition date: 2012-08-23, release date: 2012-11-14, Last modification date: 2023-09-13)
Primary citationReynald, R.L.,Sansen, S.,Stout, C.D.,Johnson, E.F.
Structural Characterization of Human Cytochrome P450 2C19: ACTIVE SITE DIFFERENCES BETWEEN P450s 2C8, 2C9, AND 2C19.
J.Biol.Chem., 287:44581-44591, 2012
Cited by
PubMed: 23118231
DOI: 10.1074/jbc.M112.424895
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.87 Å)
Structure validation

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