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4GQS

Structure of Human Microsomal Cytochrome P450 (CYP) 2C19

Functional Information from GO Data
ChainGOidnamespacecontents
A0001676biological_processlong-chain fatty acid metabolic process
A0004497molecular_functionmonooxygenase activity
A0005506molecular_functioniron ion binding
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005886cellular_componentplasma membrane
A0006631biological_processfatty acid metabolic process
A0006805biological_processxenobiotic metabolic process
A0008202biological_processsteroid metabolic process
A0008392molecular_functionarachidonic acid epoxygenase activity
A0008395molecular_functionsteroid hydroxylase activity
A0016020cellular_componentmembrane
A0016098biological_processmonoterpenoid metabolic process
A0016491molecular_functionoxidoreductase activity
A0016705molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A0016712molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
A0018675molecular_function(S)-limonene 6-monooxygenase activity
A0018676molecular_function(S)-limonene 7-monooxygenase activity
A0019373biological_processepoxygenase P450 pathway
A0019825molecular_functionoxygen binding
A0019899molecular_functionenzyme binding
A0020037molecular_functionheme binding
A0042178biological_processxenobiotic catabolic process
A0043231cellular_componentintracellular membrane-bounded organelle
A0046872molecular_functionmetal ion binding
A0052741molecular_function(R)-limonene 6-monooxygenase activity
A0070330molecular_functionaromatase activity
A0097267biological_processomega-hydroxylase P450 pathway
A0120319molecular_functionlong-chain fatty acid omega-1 hydroxylase activity
B0001676biological_processlong-chain fatty acid metabolic process
B0004497molecular_functionmonooxygenase activity
B0005506molecular_functioniron ion binding
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005886cellular_componentplasma membrane
B0006631biological_processfatty acid metabolic process
B0006805biological_processxenobiotic metabolic process
B0008202biological_processsteroid metabolic process
B0008392molecular_functionarachidonic acid epoxygenase activity
B0008395molecular_functionsteroid hydroxylase activity
B0016020cellular_componentmembrane
B0016098biological_processmonoterpenoid metabolic process
B0016491molecular_functionoxidoreductase activity
B0016705molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
B0016712molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
B0018675molecular_function(S)-limonene 6-monooxygenase activity
B0018676molecular_function(S)-limonene 7-monooxygenase activity
B0019373biological_processepoxygenase P450 pathway
B0019825molecular_functionoxygen binding
B0019899molecular_functionenzyme binding
B0020037molecular_functionheme binding
B0042178biological_processxenobiotic catabolic process
B0043231cellular_componentintracellular membrane-bounded organelle
B0046872molecular_functionmetal ion binding
B0052741molecular_function(R)-limonene 6-monooxygenase activity
B0070330molecular_functionaromatase activity
B0097267biological_processomega-hydroxylase P450 pathway
B0120319molecular_functionlong-chain fatty acid omega-1 hydroxylase activity
C0001676biological_processlong-chain fatty acid metabolic process
C0004497molecular_functionmonooxygenase activity
C0005506molecular_functioniron ion binding
C0005737cellular_componentcytoplasm
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005886cellular_componentplasma membrane
C0006631biological_processfatty acid metabolic process
C0006805biological_processxenobiotic metabolic process
C0008202biological_processsteroid metabolic process
C0008392molecular_functionarachidonic acid epoxygenase activity
C0008395molecular_functionsteroid hydroxylase activity
C0016020cellular_componentmembrane
C0016098biological_processmonoterpenoid metabolic process
C0016491molecular_functionoxidoreductase activity
C0016705molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
C0016712molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
C0018675molecular_function(S)-limonene 6-monooxygenase activity
C0018676molecular_function(S)-limonene 7-monooxygenase activity
C0019373biological_processepoxygenase P450 pathway
C0019825molecular_functionoxygen binding
C0019899molecular_functionenzyme binding
C0020037molecular_functionheme binding
C0042178biological_processxenobiotic catabolic process
C0043231cellular_componentintracellular membrane-bounded organelle
C0046872molecular_functionmetal ion binding
C0052741molecular_function(R)-limonene 6-monooxygenase activity
C0070330molecular_functionaromatase activity
C0097267biological_processomega-hydroxylase P450 pathway
C0120319molecular_functionlong-chain fatty acid omega-1 hydroxylase activity
D0001676biological_processlong-chain fatty acid metabolic process
D0004497molecular_functionmonooxygenase activity
D0005506molecular_functioniron ion binding
D0005737cellular_componentcytoplasm
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0005886cellular_componentplasma membrane
D0006631biological_processfatty acid metabolic process
D0006805biological_processxenobiotic metabolic process
D0008202biological_processsteroid metabolic process
D0008392molecular_functionarachidonic acid epoxygenase activity
D0008395molecular_functionsteroid hydroxylase activity
D0016020cellular_componentmembrane
D0016098biological_processmonoterpenoid metabolic process
D0016491molecular_functionoxidoreductase activity
D0016705molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
D0016712molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
D0018675molecular_function(S)-limonene 6-monooxygenase activity
D0018676molecular_function(S)-limonene 7-monooxygenase activity
D0019373biological_processepoxygenase P450 pathway
D0019825molecular_functionoxygen binding
D0019899molecular_functionenzyme binding
D0020037molecular_functionheme binding
D0042178biological_processxenobiotic catabolic process
D0043231cellular_componentintracellular membrane-bounded organelle
D0046872molecular_functionmetal ion binding
D0052741molecular_function(R)-limonene 6-monooxygenase activity
D0070330molecular_functionaromatase activity
D0097267biological_processomega-hydroxylase P450 pathway
D0120319molecular_functionlong-chain fatty acid omega-1 hydroxylase activity
Functional Information from PDB Data
site_idAC1
Number of Residues19
DetailsBINDING SITE FOR RESIDUE HEM A 501
ChainResidue
AARG97
ASER365
AHIS368
APRO427
APHE428
ASER429
AARG433
ACYS435
AVAL436
AGLY437
AHOH612
AILE112
ATRP120
AARG124
AALA297
AGLY298
ATHR301
ATHR302
ATHR305

site_idAC2
Number of Residues12
DetailsBINDING SITE FOR RESIDUE 0XV A 502
ChainResidue
APHE114
AILE205
AVAL208
AASP293
AALA297
AGLU300
ATHR301
AILE362
ALEU366
APHE476
AHOH601
AHOH612

site_idAC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE GOL A 503
ChainResidue
AVAL331
AARG335
AHOH604

site_idAC4
Number of Residues2
DetailsBINDING SITE FOR RESIDUE GOL A 504
ChainResidue
APHE226
APHE226

site_idAC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL A 505
ChainResidue
AILE42
AGLN214
AILE215
AASN218
AHOH609

site_idAC6
Number of Residues21
DetailsBINDING SITE FOR RESIDUE HEM B 501
ChainResidue
BARG97
BILE112
BTRP120
BARG124
BALA297
BGLY298
BTHR301
BTHR302
BTHR305
BILE362
BSER365
BHIS368
BPRO427
BPHE428
BSER429
BARG433
BCYS435
BVAL436
BGLY437
BALA441
B0XV502

site_idAC7
Number of Residues11
DetailsBINDING SITE FOR RESIDUE 0XV B 502
ChainResidue
BVAL113
BPHE114
BASP293
BGLY296
BALA297
BGLU300
BTHR301
BILE362
BLEU366
BHEM501
BHOH601

site_idAC8
Number of Residues19
DetailsBINDING SITE FOR RESIDUE HEM C 501
ChainResidue
CARG97
CILE112
CVAL113
CTRP120
CARG124
CALA297
CGLY298
CTHR301
CTHR302
CTHR305
CSER365
CHIS368
CPRO427
CPHE428
CSER429
CARG433
CCYS435
CVAL436
CGLY437

site_idAC9
Number of Residues10
DetailsBINDING SITE FOR RESIDUE 0XV C 502
ChainResidue
CLEU366
CPHE476
CHOH601
CPHE114
CILE205
CASP293
CALA297
CGLU300
CTHR301
CILE362

site_idBC1
Number of Residues20
DetailsBINDING SITE FOR RESIDUE HEM D 501
ChainResidue
DARG97
DILE112
DVAL113
DTRP120
DARG124
DLEU294
DALA297
DGLY298
DTHR301
DTHR302
DGLN356
DILE362
DSER365
DHIS368
DPRO427
DPHE428
DSER429
DARG433
DCYS435
DVAL436

site_idBC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE 0XV D 502
ChainResidue
DILE205
DASP293
DALA297
DGLU300
DILE362
DLEU366
DHOH601

Functional Information from PROSITE/UniProt
site_idPS00086
Number of Residues10
DetailsCYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FSaGKRICVG
ChainResidueDetails
APHE428-GLY437

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: axial binding residue => ECO:0000269|PubMed:23118231, ECO:0007744|PDB:4GQS
ChainResidueDetails
ACYS435
BCYS435
CCYS435
DCYS435

219515

PDB entries from 2024-05-08

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