4GQS
Structure of Human Microsomal Cytochrome P450 (CYP) 2C19
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Cytochrome P450 2C19 | polymer | 477 | 54581.0 | 4 | UniProt (P33261) Pfam (PF00067) | Homo sapiens (human) | (R)-limonene 6-monooxygenase, (S)-limonene 6-monooxygenase, (S)-limonene 7-monooxygenase, CYPIIC17, CYPIIC19, Cytochrome P450-11A, Cytochrome P450-254C, Mephenytoin 4-hydroxylase |
| 2 | E, J, L, N (A, B, C, D) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
| 3 | F, K, M, O (A, B, C, D) | (4-hydroxy-3,5-dimethylphenyl)(2-methyl-1-benzofuran-3-yl)methanone | non-polymer | 280.3 | 4 | Chemie (0XV) | |||
| 4 | G, H, I (A) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 5 | P, Q, R, S (A, B, C, D) | water | water | 18.0 | 50 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 23 - 489 (UniProt: P33261)
| PDB | External Database | Details |
|---|---|---|
| Met 18 | - | expression tag |
| Ala 19 | - | expression tag |
| Lys 20 | - | expression tag |
| Lys 21 | - | expression tag |
| Thr 22 | - | expression tag |
| Ile 490 | - | expression tag |
| His 491 | - | expression tag |
| His 492 | - | expression tag |
| His 493 | - | expression tag |
| His 494 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 218324.0 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 3863.5 | |
| All* | Total formula weight | 222187.5 |
