4GQS
Structure of Human Microsomal Cytochrome P450 (CYP) 2C19
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Cytochrome P450 2C19 | polymer | 477 | 54581.0 | 4 | UniProt (P33261) Pfam (PF00067) In PDB | Homo sapiens (human) | (R)-limonene 6-monooxygenase, (S)-limonene 6-monooxygenase, (S)-limonene 7-monooxygenase, CYPIIC17, CYPIIC19, Cytochrome P450-11A, Cytochrome P450-254C, Mephenytoin 4-hydroxylase |
2 | A, B, C, D | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
3 | A, B, C, D | (4-hydroxy-3,5-dimethylphenyl)(2-methyl-1-benzofuran-3-yl)methanone | non-polymer | 280.3 | 4 | Chemie (0XV) | |||
4 | A | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
5 | water | water | 18.0 | 50 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 23 - 489 (UniProt: P33261)
PDB | External Database | Details |
---|---|---|
Met 18 | - | expression tag |
Ala 19 | - | expression tag |
Lys 20 | - | expression tag |
Lys 21 | - | expression tag |
Thr 22 | - | expression tag |
Ile 490 | - | expression tag |
His 491 | - | expression tag |
His 492 | - | expression tag |
His 493 | - | expression tag |
His 494 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 218324.0 | |
Non-Polymers* | Number of molecules | 11 |
Total formula weight | 3863.5 | |
All* | Total formula weight | 222187.5 |