1R9O

Crystal Structure of P4502C9 with Flurbiprofen bound

Summary for 1R9O

• Entry DOI: 10.2210/pdb1r9o/pdb
• Related: 1N6B 1NR6 1OG5 1PO5 1PQ2
• Descriptor: Cytochrome P450 2C9, PROTOPORPHYRIN IX CONTAINING FE, FLURBIPROFEN, ... (5 entities in total)
• Functional Keywords: p450, monooxygenase, drug metabolizing enzyme, oxidoreductase, heme
• Biological source: Homo sapiens (human)
• Cellular location: Endoplasmic reticulum membrane; Peripheral membrane protein: P11712
• Total number of polymer chains: 1
• Total formula weight: 55275.73

Authors

Wester, M.R.,Yano, J.K.,Schoch, G.A.,Griffin, K.J.,Stout, C.D.,Johnson, E.F. (deposition date: 2003-10-30, release date: 2004-06-15, Last modification date: 2023-08-23)

• Primary citation: Wester, M.R.,Yano, J.K.,Schoch, G.A.,Yang, C.,Griffin, K.J.,Stout, C.D.,Johnson, E.F.; The Structure of Human Cytochrome P450 2C9 Complexed with Flurbiprofen at 2.0 A Resolution; J.Biol.Chem., 279:35630-35637, 2004; PubMed: 15181000; DOI: 10.1074/jbc.M405427200

Experimental method

X-RAY DIFFRACTION (2 Å)