4DJ9

Human vinculin head domain Vh1 (residues 1-258) in complex with the talin vinculin binding site 50 (VBS50, residues 2078-2099)

Summary for 4DJ9

• Entry DOI: 10.2210/pdb4dj9/pdb
• Related: 1rkc 1rke 1syq 3s90 3tj5 3tj6
• Descriptor: Vinculin, Talin-1 (3 entities in total)
• Functional Keywords: cytoskeleton, focal adhesion, protein-protein interaction, four-helix bundle, cell adhesion, f-actin, cytosol
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm, cytoskeleton: P18206; Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity): Q9Y490
• Total number of polymer chains: 2
• Total formula weight: 31807.72

Authors

Yogesha, S.D.,Rangarajan, E.S.,Vonrhein, C.,Bricogne, G.,Izard, T. (deposition date: 2012-02-01, release date: 2012-02-29, Last modification date: 2024-02-28)

• Primary citation: Yogesha, S.D.,Rangarajan, E.S.,Vonrhein, C.,Bricogne, G.,Izard, T.; Crystal structure of vinculin in complex with vinculin binding site 50 (VBS50), the integrin binding site 2 (IBS2) of talin.; Protein Sci., 21:583-588, 2012; PubMed: 22334306; DOI: 10.1002/pro.2041

Experimental method

X-RAY DIFFRACTION (2.25 Å)