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4B7E

FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH CONSENSUS ANKYRIN REPEAT DOMAIN-LEU PEPTIDE (20-MER)

Summary for 4B7E
Entry DOI10.2210/pdb4b7e/pdb
Related1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGN 2CGO 2W0X 2WA3 2WA4 2XUM 2Y0I 2YC0 2YDE 4AI8
DescriptorHYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR, CONSENSUS ANKYRIN REPEAT DOMAIN-LEU, ZINC ION, ... (7 entities in total)
Functional Keywordsoxidoreductase-peptide complex, oxidoreductase, non-heme, iron, 2-oxoglutarate, dioxygenase, oxygenase, dna-binding, metal-binding, transcription, helix-loop-helix-beta, dsbh, facial triad, asparaginyl/ aspartyl hydroxylase, transcription and epigenetic regulation, signaling, ard, beta-hydroxylation, transcription activator/inhibitor, oxidoreductase/peptide
Biological sourceHOMO SAPIENS (HUMAN)
More
Cellular locationNucleus: Q9NWT6
Total number of polymer chains2
Total formula weight43240.57
Authors
Chowdhury, R.,Ge, W.,Schofield, C.J. (deposition date: 2012-08-17, release date: 2013-01-23, Last modification date: 2023-12-20)
Primary citationYang, M.,Hardy, A.P.,Chowdhury, R.,Loik, N.D.,Scotti, J.S.,McCullagh, J.S.,Claridge, T.D.,McDonough, M.A.,Ge, W.,Schofield, C.J.
Substrate selectivity analyses of factor inhibiting hypoxia-inducible factor.
Angew. Chem. Int. Ed. Engl., 52:1700-1704, 2013
Cited by
PubMed: 23296631
DOI: 10.1002/anie.201208046
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

217705

건을2024-03-27부터공개중

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