4B7E

FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH CONSENSUS ANKYRIN REPEAT DOMAIN-LEU PEPTIDE (20-MER)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0003714	molecular_function	transcription corepressor activity
A	0005112	molecular_function	Notch binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0008198	molecular_function	ferrous iron binding
A	0008270	molecular_function	zinc ion binding
A	0009966	biological_process	regulation of signal transduction
A	0016491	molecular_function	oxidoreductase activity
A	0019826	molecular_function	oxygen sensor activity
A	0030947	biological_process	regulation of vascular endothelial growth factor receptor signaling pathway
A	0031406	molecular_function	carboxylic acid binding
A	0036139	molecular_function	peptidyl-histidine dioxygenase activity
A	0036140	molecular_function	[protein]-asparagine 3-dioxygenase activity
A	0042803	molecular_function	protein homodimerization activity
A	0045663	biological_process	positive regulation of myoblast differentiation
A	0045746	biological_process	negative regulation of Notch signaling pathway
A	0046872	molecular_function	metal ion binding
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0050793	biological_process	regulation of developmental process
A	0051059	molecular_function	NF-kappaB binding
A	0051213	molecular_function	dioxygenase activity
A	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
A	0062101	molecular_function	peptidyl-aspartic acid 3-dioxygenase activity
A	0071532	molecular_function	ankyrin repeat binding
A	2001214	biological_process	positive regulation of vasculogenesis

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 501

Chain	Residue
A	HIS199
A	ASP201
A	HIS279
A	OGA601

---

site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE OGA A 601

Chain	Residue
A	ASN205
A	PHE207
A	LYS214
A	HIS279
A	ILE281
A	ASN294
A	TRP296
A	ZN501
A	HOH2096
B	LEU16
A	TYR145
A	LEU188
A	THR196
A	HIS199
A	ASP201

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 602

Chain	Residue
A	THR97
A	HIS98
A	ARG143
A	HOH2018

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 603

Chain	Residue
A	TYR230
A	SER240
A	VAL242
A	ASP243
A	HOH2115

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 604

Chain	Residue
A	ARG138
A	GLY140
A	GLU141
A	GLU142

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 605

Chain	Residue
A	ARG143
A	GLU192
A	LEU285
A	ASN286

---

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 606

Chain	Residue
A	PRO221
A	LYS311
A	ALA312
A	HIS313
A	HOH2038
A	HOH2105
A	HOH2136
A	HOH2157

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 607

Chain	Residue
A	ALA3
A	TRP167
A	ASN171
A	HOH2159

---

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 608

Chain	Residue
A	SER91
A	TYR93
A	GLN147
A	GLN148
A	THR149
A	HOH2075
B	GLN18

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 609

Chain	Residue
A	ASP222
A	PHE224
A	GLU225
A	LYS315
A	MET319

---

site_id	BC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GOL A 610

Chain	Residue
A	ARG120

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	170
Details	Domain: {"description":"JmjC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	50
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	123
Details	Region: {"description":"Interaction with VHL","evidences":[{"source":"PubMed","id":"11641274","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	9
Details	Compositional bias: {"description":"Low complexity","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12432100","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12446723","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21251231","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21177872","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12432100","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12446723","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15913349","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17135241","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20396966","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20822901","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21251231","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21460794","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Site: {"description":"Important for dimer formation"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---