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4AW0

Human PDK1 Kinase Domain in Complex with Allosteric Compound PS182 Bound to the PIF-Pocket

Summary for 4AW0
Entry DOI10.2210/pdb4aw0/pdb
Related1H1W 1OKY 1OKZ 1UU3 1UU7 1UU8 1UU9 1UVR 1W1D 1W1G 1W1H 1Z5M 2BIY 2VKI 2XCH 2XCK 4A06 4A07 4AW1
Descriptor3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1, ADENOSINE-5'-TRIPHOSPHATE, [(1R)-3-(4-chlorophenyl)-3-oxo-1-phenylpropyl]propanedioic acid, ... (7 entities in total)
Functional Keywordstransferase, allosteric regulation, allosteric site, phosphorylation, agc protein kinase
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCytoplasm: O15530
Total number of polymer chains1
Total formula weight36601.61
Authors
Schulze, J.O.,Busschots, K.,Lopez-Garcia, L.A.,Lammi, C.,Stroba, A.,Zeuzem, S.,Piiper, A.,Alzari, P.M.,Neimanis, S.,Arencibia, J.M.,Engel, M.,Biondi, R.M. (deposition date: 2012-05-30, release date: 2012-10-03, Last modification date: 2023-12-20)
Primary citationBusschots, K.,Lopez-Garcia, L.A.,Lammi, C.,Stroba, A.,Zeuzem, S.,Piiper, A.,Alzari, P.M.,Neimanis, S.,Arencibia, J.M.,Engel, M.,Schulze, J.O.,Biondi, R.M.
Substrate-Selective Inhibition of Protein Kinase Pdk1 by Small Compounds that Bind to the Pif-Pocket Allosteric Docking Site.
Chem.Biol., 19:1152-, 2012
Cited by
PubMed: 22999883
DOI: 10.1016/J.CHEMBIOL.2012.07.017
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.43 Å)
Structure validation

217705

건을2024-03-27부터공개중

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