1OKY

Structure of human PDK1 kinase domain in complex with staurosporine

Summary for 1OKY

Related1H1W 1OKZ 1UU3 1UU7 1UU8 1UU9 1UVR
Descriptor3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1, GLYCEROL, SULFATE ION, ... (5 entities in total)
Functional Keywordsprotein kinase, pkb, pdk1, staurosporine, transferase
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains1
Total molecular weight36721.82
Authors
Komander, D.,Kular, G.S.,Alessi, D.R.,Van Aalten, D.M.F. (deposition date: 2003-08-01, release date: 2004-07-29, Last modification date: 2019-04-24)
Primary citation
Komander, D.,Kular, G.S.,Bain, J.,Elliot, M.,Alessi, D.R.,Van Aalten, D.M.F.
Structural Basis for Ucn-01 (7-Hydroxystaurosporine) Specificity and Pdk1 (3-Phosphoinositide-Dependent Protein Kinase-1) Inhibition
Biochem.J., 375:255-, 2003
PubMed: 12892559 (PDB entries with the same primary citation)
DOI: 10.1042/BJ20031119
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.23813 0.7% 3.3% 5.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 1oky
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Molmil generated image of 1oky
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Molmil generated image of 1oky
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