1OKZ

Structure of human PDK1 kinase domain in complex with UCN-01

Summary for 1OKZ

Related1H1W 1OKY 1UU3 1UU7 1UU8 1UU9 1UVR
Descriptor3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1, GLYCEROL, SULFATE ION, ... (5 entities in total)
Functional Keywordsprotein kinase, pkb, pdk1, ucn-01, 7-hydroxy staurosporine, inhibitor, transferase, atp-binding, phosphorylation
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains1
Total molecular weight37014.1
Authors
Komander, D.,Kular, G.S.,Alessi, D.R.,Van Aalten, D.M.F. (deposition date: 2003-08-01, release date: 2004-07-29, Last modification date: 2019-04-24)
Primary citation
Komander, D.,Kular, G.S.,Bain, J.,Elliot, M.,Alessi, D.R.,Van Aalten, D.M.F.
Structural Basis for Ucn-01 (7-Hydroxystaurosporine) Specificity and Pdk1 (3-Phosphoinositide-Dependent Protein Kinase-1) Inhibition
Biochem.J., 375:255-, 2003
PubMed: 12892559 (PDB entries with the same primary citation)
DOI: 10.1042/BJ20031119
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.51 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2529 0.4% 4.3% 3.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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