4ARA

Mus musculus Acetylcholinesterase in complex with (R)-C5685 at 2.5 A resolution.

Summary for 4ARA

Entry DOI	10.2210/pdb4ara/pdb
Related	1C2B 1C2O 1J06 1J07 1KU6 1MAA 1MAH 1N5M 1N5R 1Q83 1Q84 2C0P 2C0Q 2H9Y 2HA0 2HA2 2HA3 2HA4 2HA5 2HA6 2HA7 2JEY 2JEZ 2JF0 2JGE 2JGF 2JGG 2JGH 2JGI 2JGJ 2JGK 2JGL 2JGM 2WHP 2WHQ 2WHR 2WLS 2WU3 2WU4 2XUD 2XUF 2XUG 2XUH 2XUI 2XUJ 2XUK 2XUO 2XUP 2XUQ 4A16 4A23 4ARB
Descriptor	ACETYLCHOLINESTERASE, 4-(DIMETHYLAMINO)-N-{[(2R)-1-ETHYLPYRROLIDIN-2-YL]METHYL}-2-METHOXY-5-NITROBENZAMIDE, DI(HYDROXYETHYL)ETHER, ... (8 entities in total)
Functional Keywords	hydrolase, enatiomers, inhibitor, chemical lead
Biological source	Mus musculus (house mouse)
Total number of polymer chains	2
Total formula weight	123557.77
Authors	Berg, L.,Niemiec, M.S.,Qian, W.,Andersson, C.D.,WittungStafshede, P.,Ekstrom, F.,Linusson, A. (deposition date: 2012-04-23, release date: 2012-11-28, Last modification date: 2023-12-20)
Primary citation	Berg, L.,Niemiec, M.S.,Qian, W.,Andersson, C.D.,Wittung-Stafshede, P.,Ekstrom, F.,Linusson, A. Similar But Different: Thermodynamic and Structural Characterization of a Pair of Enantiomers Binding to Acetylcholinesterase. Angew.Chem.Int.Ed.Engl., 51:12716-, 2012 Cited by PubMed: 23161758 DOI: 10.1002/ANIE.201205113 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation