2WU4

CRYSTAL STRUCTURE OF MOUSE ACETYLCHOLINESTERASE IN COMPLEX WITH FENAMIPHOS AND ORTHO-7

Summary for 2WU4

Entry DOI	10.2210/pdb2wu4/pdb
Related	1C2B 1C2O 1J06 1J07 1KU6 1MAA 1MAH 1N5M 1N5R 1Q83 1Q84 2C0P 2C0Q 2H9Y 2HA0 2HA2 2HA3 2HA4 2HA5 2HA6 2HA7 2JEY 2JEZ 2JF0 2JGE 2JGF 2JGG 2JGH 2JGI 2JGJ 2JGK 2JGL 2JGM 2WHP 2WHQ 2WHR 2WLS 2WU3
Descriptor	ACETYLCHOLINESTERASE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 1,7-HEPTYLENE-BIS-N,N'-SYN-2-PYRIDINIUMALDOXIME, ... (5 entities in total)
Functional Keywords	glycoprotein, serine esterase, acetylcholinesterase, alternative splicing, neurotransmitter degradation, synapse, membrane, hydrolase, fenamiphos
Biological source	MUS MUSCULUS (MOUSE)
Total number of polymer chains	2
Total formula weight	121954.63
Authors	Hornberg, A.,Artursson, E.,Warme, R.,Pang, Y.-P.,Ekstrom, F. (deposition date: 2009-09-28, release date: 2009-10-20, Last modification date: 2023-12-20)
Primary citation	Hornberg, A.,Artursson, E.,Warme, R.,Pang, Y.-P.,Ekstrom, F. Crystal Structures of Oxime-Bound Fenamiphos-Acetylcholinesterases: Reactivation Involving Flipping of the His447 Ring to Form a Reactive Glu334-His447-Oxime Triad. Biochem.Pharm., 79:507-, 2010 Cited by PubMed: 19732756 DOI: 10.1016/J.BCP.2009.08.027 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation