4AMJ
Turkey beta1 adrenergic receptor with stabilising mutations and bound biased agonist carvedilol
Summary for 4AMJ
| Entry DOI | 10.2210/pdb4amj/pdb |
| Related | 1DEP 2VT4 2Y00 2Y01 2Y02 2Y03 2Y04 2YCW 2YCX 2YCY 2YCZ 4AMI |
| Descriptor | BETA-1 ADRENERGIC RECEPTOR, (2S)-1-(8H-CARBAZOL-4-YLOXY)-3-[2-(2-METHOXYPHENOXY)ETHYLAMINO]PROPAN-2-OL, SODIUM ION, ... (5 entities in total) |
| Functional Keywords | membrane protein, 7tmr beta1-adrenoceptor, stabilising mutations, biased agonist |
| Biological source | MELEAGRIS GALLOPAVO (TURKEY) |
| Total number of polymer chains | 2 |
| Total formula weight | 77294.35 |
| Authors | Warne, T.,Edwards, P.C.,Leslie, A.G.,Tate, C.G. (deposition date: 2012-03-12, release date: 2012-05-23, Last modification date: 2023-12-20) |
| Primary citation | Warne, T.,Edwards, P.C.,Leslie, A.G.,Tate, C.G. Crystal Structures of a Stabilized Beta1-Adrenoceptor Bound to the Biased Agonists Bucindolol and Carvedilol Structure, 20:841-, 2012 Cited by PubMed: 22579251DOI: 10.1016/J.STR.2012.03.014 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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