4AIC

X-ray structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXR, Rv2870c, from Mycobacterium tuberculosis, in complex with fosmidomycin, manganese and NADPH

Replaces:  2JCZ

Summary for 4AIC

• Entry DOI: 10.2210/pdb4aic/pdb
• Related: 2C82 2JCV 2JCX 2JCY 2JD0 2JD1 2JD2 2Y1C 2Y1D 2Y1E 2Y1F 2Y1G 4A03
• Descriptor: 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, 3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC ACID, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (6 entities in total)
• Functional Keywords: oxidoreductase, doxp/mep pathway
• Biological source: MYCOBACTERIUM TUBERCULOSIS
• Total number of polymer chains: 2
• Total formula weight: 85377.89

Authors

Henriksson, L.M.,Unge, T.,Jones, T.A.,Mowbray, S.L. (deposition date: 2012-02-09, release date: 2012-02-22, Last modification date: 2023-12-20)

• Primary citation: Henriksson, L.M.,Unge, T.,Carlsson, J.,Aqvist, J.,Mowbray, S.L.,Jones, T.A.; Structures of Mycobacterium Tuberculosis 1-Deoxy-D-Xylulose- 5-Phosphate Reductoisomerase Provide New Insights Into Catalysis.; J.Biol.Chem., 282:19905-, 2007; PubMed: 17491006; DOI: 10.1074/JBC.M701935200

Experimental method

X-RAY DIFFRACTION (2.05 Å)