2Y1G

X-ray structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXR, Rv2870c, from Mycobacterium tuberculosis, in complex with a 3,4- dichlorophenyl-substituted FR900098 analogue and manganese.

Summary for 2Y1G

Entry DOI	10.2210/pdb2y1g/pdb
Related	2Y1C 2Y1D 2Y1E 2Y1F
Descriptor	1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, 3-(N-HYDROXYACETAMIDO)-1-(3,4-DICHLOROPHENYL)PROPYLPHOSPHONIC ACID, MANGANESE (II) ION, ... (5 entities in total)
Functional Keywords	oxidoreductase, doxp/mep pathway
Biological source	MYCOBACTERIUM TUBERCULOSIS
Total number of polymer chains	2
Total formula weight	84142.12
Authors	Henriksson, L.M.,Larsson, A.M.S.,Bergfors, T.,Bjorkelid, C.,Unge, T.,Mowbray, S.L.,Jones, T.A. (deposition date: 2010-12-08, release date: 2011-06-29, Last modification date: 2023-12-20)
Primary citation	Andaloussi, M.,Henriksson, L.M.,Wieckowska, A.,Lindh, M.,Bjorkelid, C.,Larsson, A.M.S.,Iyer, H.,Srinivasa, B.R.,Bergfors, T.,Unge, T.,Mowbray, S.L.,Larhed, M.,Jones, T.A.,Karlen, A. Design, Synthesis and X-Ray Crystallographic Studies of Alpha-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium Tuberculosis 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase J.Med.Chem, 54:4964-, 2011 Cited by PubMed: 21678907 DOI: 10.1021/JM2000085 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation