2Y1G
X-ray structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXR, Rv2870c, from Mycobacterium tuberculosis, in complex with a 3,4- dichlorophenyl-substituted FR900098 analogue and manganese.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0030604 | molecular_function | 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070402 | molecular_function | NADPH binding |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0030604 | molecular_function | 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070402 | molecular_function | NADPH binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE FM5 A 1390 |
| Chain | Residue |
| A | LYS128 |
| A | LYS219 |
| A | GLU222 |
| A | SER245 |
| A | PRO265 |
| A | MN1391 |
| A | HOH2176 |
| A | HOH2178 |
| A | HOH2262 |
| A | ASP151 |
| A | SER152 |
| A | GLU153 |
| A | ALA176 |
| A | SER177 |
| A | MET205 |
| A | SER213 |
| A | ASN218 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN A 1391 |
| Chain | Residue |
| A | ASP151 |
| A | GLU153 |
| A | GLU222 |
| A | FM51390 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1392 |
| Chain | Residue |
| A | THR21 |
| A | GLY47 |
| A | GLY48 |
| A | ALA49 |
| A | HIS50 |
| A | HOH2263 |
| A | HOH2264 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1393 |
| Chain | Residue |
| A | ARG162 |
| A | TRP277 |
| A | PRO278 |
| A | HOH2120 |
| A | HOH2265 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN B 1390 |
| Chain | Residue |
| B | ASP151 |
| B | GLU153 |
| B | GLU222 |
| B | HOH2308 |
| B | HOH2309 |
| B | HOH2310 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1391 |
| Chain | Residue |
| B | ALA176 |
| B | SER177 |
| B | SER213 |
| B | ASN218 |
| B | LYS219 |
| B | HOH2310 |
| B | HOH2311 |
| B | HOH2312 |
| B | HOH2313 |
| B | HOH2314 |
