2Y1G
X-ray structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXR, Rv2870c, from Mycobacterium tuberculosis, in complex with a 3,4- dichlorophenyl-substituted FR900098 analogue and manganese.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE | polymer | 398 | 41701.0 | 2 | UniProt (A2VLK3) | MYCOBACTERIUM TUBERCULOSIS | DXP REDUCTOISOMERASE, 1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERASE, 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE SYNTHASE |
| 2 | C (A) | 3-(N-HYDROXYACETAMIDO)-1-(3,4-DICHLOROPHENYL)PROPYLPHOSPHONIC ACID | non-polymer | 342.1 | 1 | Chemie (FM5) | |||
| 3 | D, G (A, B) | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
| 4 | E, F, H (A, B) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 579 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 389 (UniProt: A2VLK3)
| PDB | External Database | Details |
|---|---|---|
| Thr -8 | - | expression tag |
| Met -7 | - | expression tag |
| Ala -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 83401.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 740.2 | |
| All* | Total formula weight | 84142.1 |
