4AIC
X-ray structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXR, Rv2870c, from Mycobacterium tuberculosis, in complex with fosmidomycin, manganese and NADPH
Replaces: 2JCZFunctional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0030604 | molecular_function | 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050897 | molecular_function | cobalt ion binding |
| A | 0051483 | biological_process | terpenoid biosynthetic process, mevalonate-independent |
| A | 0051484 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process |
| A | 0070402 | molecular_function | NADPH binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0030604 | molecular_function | 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0050897 | molecular_function | cobalt ion binding |
| B | 0051483 | biological_process | terpenoid biosynthetic process, mevalonate-independent |
| B | 0051484 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process |
| B | 0070402 | molecular_function | NADPH binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE FOM A 1390 |
| Chain | Residue |
| A | LYS128 |
| A | ASN218 |
| A | LYS219 |
| A | GLU222 |
| A | NDP1391 |
| A | MN1392 |
| A | HOH2133 |
| A | HOH2134 |
| A | HOH2156 |
| A | ASP151 |
| A | SER152 |
| A | GLU153 |
| A | ALA176 |
| A | SER177 |
| A | HIS200 |
| A | TRP203 |
| A | SER213 |
| site_id | AC2 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE NDP A 1391 |
| Chain | Residue |
| A | GLY19 |
| A | THR21 |
| A | GLY22 |
| A | SER23 |
| A | ILE24 |
| A | ALA46 |
| A | GLY47 |
| A | GLY48 |
| A | ALA49 |
| A | HIS50 |
| A | ALA69 |
| A | ALA103 |
| A | LEU104 |
| A | ALA126 |
| A | ASN127 |
| A | LYS128 |
| A | GLU129 |
| A | ASP151 |
| A | MET205 |
| A | GLY206 |
| A | ASN209 |
| A | MET267 |
| A | FOM1390 |
| A | HOH2002 |
| A | HOH2005 |
| A | HOH2008 |
| A | HOH2031 |
| A | HOH2064 |
| A | HOH2104 |
| A | HOH2237 |
| A | HOH2238 |
| A | HOH2239 |
| A | HOH2240 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN A 1392 |
| Chain | Residue |
| A | LYS128 |
| A | ASP151 |
| A | GLU153 |
| A | GLU222 |
| A | FOM1390 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1393 |
| Chain | Residue |
| A | ARG162 |
| A | TRP277 |
| A | PRO278 |
| A | HOH2120 |
| A | HOH2186 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN B 1390 |
| Chain | Residue |
| B | ASP151 |
| B | GLU153 |
| B | GLU222 |
| B | HOH2110 |
| B | HOH2111 |
| B | HOH2116 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1391 |
| Chain | Residue |
| B | ALA176 |
| B | SER177 |
| B | SER213 |
| B | ASN218 |
| B | LYS219 |
| B | HOH2116 |
| B | HOH2132 |
| B | HOH2155 |
| B | HOH2160 |
| site_id | AC7 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE NDP B 1392 |
| Chain | Residue |
| B | GLY19 |
| B | THR21 |
| B | GLY22 |
| B | ALA46 |
| B | GLY47 |
| B | GLY48 |
| B | ALA49 |
| B | HIS50 |
| B | ALA69 |
| B | LEU104 |
| B | VAL105 |
| B | LEU108 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 36 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00183","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
