4AI8

FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH DAMINOZIDE

Summary for 4AI8

• Entry DOI: 10.2210/pdb4ai8/pdb
• Related: 1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGN 2CGO 2W0X 2WA3 2WA4 2XUM 2Y0I 2YC0 2YDE
• Descriptor: HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR, SULFATE ION, GLYCEROL, ... (6 entities in total)
• Functional Keywords: oxidoreductase, dioxygenase, metal-binding, helix-loop-helix-beta, dsbh, facial triad, transcription and epigenetic regulation, ankyrin repeat domain, beta-hydroxylation, transcription activator/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 41592.73

Authors

King, O.N.F.,Chowdhury, R.,Rose, N.R.,McDonough, M.A.,Clifton, I.J.,Schofield, C.J.,Kawamura, A. (deposition date: 2012-02-08, release date: 2012-10-03, Last modification date: 2023-12-20)

• Primary citation: Rose, N.R.,Woon, E.C.,Tumber, A.,Walport, L.J.,Chowdhury, R.,Li, X.S.,King, O.N.,Lejeune, C.,Ng, S.S.,Krojer, T.,Chan, M.C.,Rydzik, A.M.,Hopkinson, R.J.,Che, K.H.,Daniel, M.,Strain-Damerell, C.,Gileadi, C.,Kochan, G.,Leung, I.K.,Dunford, J.,Yeoh, K.K.,Ratcliffe, P.J.,Burgess-Brown, N.,von Delft, F.,Muller, S.,Marsden, B.,Brennan, P.E.,McDonough, M.A.,Oppermann, U.,Klose, R.J.,Schofield, C.J.,Kawamura, A.; Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.; J. Med. Chem., 55:6639-6643, 2012; PubMed: 22724510; DOI: 10.1021/jm300677j

Experimental method

X-RAY DIFFRACTION (2.4 Å)