4A92
Full-length HCV NS3-4A protease-helicase in complex with a macrocyclic protease inhibitor.
Summary for 4A92
Entry DOI | 10.2210/pdb4a92/pdb |
Related | 1A1Q 1BT7 1C2P 1CSJ 1CU1 1GX5 1GX6 1JXP 1NHU 1NHV 1NS3 1OS5 1QUV 2AWZ 2AX0 2AX1 2BRK 2BRL 2I1R 2JC0 2JC1 2WCX 2WHO 2XWY 8OHM |
Descriptor | SERINE PROTEASE NS3, ZINC ION, (1'R,2R,2'S,6S,24AS)-17-FLUORO-6-(1-METHYL-2-OXOPIPERIDINE-3-CARBOXAMIDO)-19,19-DIOXIDO-5,21,24-TRIOXO-2'-VINYL-1,2,3,5,6,7,8,9,10,11,12,13,14,20,21,23,24,24A-OCTADECAHYDROSPIRO[BENZO[S]PYRROLO[2,1-G][1,2,5,8,18]THIATETRAAZACYCLOICOSINE-22,1'-CYCLOPRO-2-CARBOXYLATEPAN]-2-YL 4-FLUOROISOINDOLINE, ... (4 entities in total) |
Functional Keywords | hydrolase, drug design |
Biological source | HEPATITIS C VIRUS (HCV) |
Total number of polymer chains | 2 |
Total formula weight | 143513.55 |
Authors | Schiering, N.,D'Arcy, A.,Simic, O.,Eder, J.,Raman, P.,Svergun, D.I.,Bodendorf, U. (deposition date: 2011-11-23, release date: 2011-12-28, Last modification date: 2024-05-08) |
Primary citation | Schiering, N.,D'Arcy, A.,Villard, F.,Simic, O.,Kamke, M.,Monnet, G.,Hassiepen, U.,Svergun, D.I.,Pulfer, R.,Eder, J.,Raman, P.,Bodendorf, U. A Macrocyclic Hcv Ns3/4A Protease Inhibitor Interacts with Protease and Helicase Residues in the Complex with its Full- Length Target. Proc.Natl.Acad.Sci.USA, 108:21052-, 2011 Cited by PubMed: 22160684DOI: 10.1073/PNAS.1110534108 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.73 Å) |
Structure validation
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