4A92

Full-length HCV NS3-4A protease-helicase in complex with a macrocyclic protease inhibitor.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004386	molecular_function	helicase activity
A	0005524	molecular_function	ATP binding
A	0006508	biological_process	proteolysis
A	0008236	molecular_function	serine-type peptidase activity
A	0019087	biological_process	symbiont-mediated transformation of host cell
B	0004386	molecular_function	helicase activity
B	0005524	molecular_function	ATP binding
B	0006508	biological_process	proteolysis
B	0008236	molecular_function	serine-type peptidase activity
B	0019087	biological_process	symbiont-mediated transformation of host cell

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 999

Chain	Residue
A	CYS97
A	CYS99
A	CYS145
A	HOH2040

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 999

Chain	Residue
B	CYS97
B	CYS99
B	CYS145
B	HIS149

---

site_id	AC3
Number of Residues	22
Details	BINDING SITE FOR RESIDUE F9K A 1721

Chain	Residue
A	PHE43
A	HIS57
A	GLY58
A	ASP79
A	ASP81
A	ARG123
A	VAL132
A	LEU135
A	LYS136
A	GLY137
A	SER138
A	SER139
A	PHE154
A	ARG155
A	ALA156
A	ALA157
A	ASP168
A	GLN526
A	ASP527
A	HIS528
A	HOH2109
A	GLN41

---

site_id	AC4
Number of Residues	22
Details	BINDING SITE FOR RESIDUE F9K B 1721

Chain	Residue
B	GLN41
B	PHE43
B	HIS57
B	GLY58
B	VAL78
B	ASP79
B	ASP81
B	ARG123
B	LEU135
B	GLY137
B	SER138
B	SER139
B	PHE154
B	ARG155
B	ALA156
B	ALA157
B	ASP168
B	VAL524
B	GLN526
B	ASP527
B	HIS528
B	HOH2006

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	304
Details	Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	22
Details	Region: {"description":"RNA-binding","evidences":[{"source":"PubMed","id":"9614113","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Motif: {"description":"DECH box","evidences":[{"source":"UniProtKB","id":"Q99IB8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Active site: {"description":"Charge relay system; for serine protease NS3 activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01166","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"8861916","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Active site: {"description":"Charge relay system; for serine protease NS3 activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01166","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"8861916","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9568891","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01166","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10366511","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8861916","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9568891","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01166","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10366511","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8861916","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9WMX2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---