1C2P
HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE
Summary for 1C2P
Entry DOI | 10.2210/pdb1c2p/pdb |
Descriptor | RNA-DEPENDENT RNA POLYMERASE (2 entities in total) |
Functional Keywords | polymerase rna-dependent rna polymerase hepatitis c virus ns5b apoenzyme, transferase |
Biological source | Hepatitis C virus |
Cellular location | Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein. Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : P26663 |
Total number of polymer chains | 2 |
Total formula weight | 129058.34 |
Authors | Lesburg, C.A.,Cable, M.B.,Ferrari, E.,Hong, Z.,Mannarino, A.F.,Weber, P.C. (deposition date: 1999-07-26, release date: 2000-04-05, Last modification date: 2024-10-09) |
Primary citation | Lesburg, C.A.,Cable, M.B.,Ferrari, E.,Hong, Z.,Mannarino, A.F.,Weber, P.C. Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site. Nat.Struct.Biol., 6:937-943, 1999 Cited by PubMed: 10504728DOI: 10.1038/13305 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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