1OS5

Crystal structure of HCV NS5B RNA polymerase complexed with a novel non-competitive inhibitor.

Summary for 1OS5

Entry DOI	10.2210/pdb1os5/pdb
Descriptor	Hepatitis C virus NS5B RNA polymerase, 3-(4-AMINO-2-TERT-BUTYL-5-METHYL-PHENYLSULFANYL)-6-CYCLOPENTYL-4-HYDROXY-6-[2-(4-HYDROXY-PHENYL)-ETHYL]-5,6-DIHYDRO-PYRAN-2-ONE (3 entities in total)
Functional Keywords	enzyme-inhibitor complex, transferase
Biological source	Hepatitis C virus
Total number of polymer chains	1
Total formula weight	64658.13
Authors	Love, R.A.,Parge, H.E.,Yu, X.,Hickey, M.J.,Diehl, W.,Gao, J.,Wriggers, H.,Ekker, A.,Wang, L.,Thomson, J.A.,Dragovich, P.S.,Fuhrman, S.A. (deposition date: 2003-03-18, release date: 2004-03-18, Last modification date: 2024-04-03)
Primary citation	Love, R.A.,Parge, H.E.,Yu, X.,Hickey, M.J.,Diehl, W.,Gao, J.,Wriggers, H.,Ekker, A.,Wang, L.,Thomson, J.A.,Dragovich, P.S.,Fuhrman, S.A. Crystallographic identification of a noncompetitive inhibitor binding site on the hepatitis C virus NS5B RNA polymerase enzyme. J.Virol., 77:7575-7581, 2003 Cited by PubMed: 12805457 DOI: 10.1128/JVI.77.13.7575-7581.2003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation