1OS5

Crystal structure of HCV NS5B RNA polymerase complexed with a novel non-competitive inhibitor.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003968	molecular_function	RNA-dependent RNA polymerase activity
A	0039694	biological_process	viral RNA genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE NH1 A 901

Chain	Residue
A	LYS270
A	HOH956
A	HOH1140
A	HOH1142
A	LEU419
A	ARG422
A	MET423
A	HIS475
A	SER476
A	TYR477
A	TRP528
A	HOH905

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000305|PubMed:10557268, ECO:0000305|PubMed:11884572

Chain	Residue	Details
A	ASP220
A	ASP318
A	ASP319

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine; by host => ECO:0000250|UniProtKB:P26662

Chain	Residue	Details
A	SER29
A	SER42

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