1OS5

Crystal structure of HCV NS5B RNA polymerase complexed with a novel non-competitive inhibitor.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Hepatitis C virus NS5B RNA polymerase	polymer	576	64162.5	1	UniProt (P26663) Pfam (PF00998) In PDB	Hepatitis C virus
2	A	3-(4-AMINO-2-TERT-BUTYL-5-METHYL-PHENYLSULFANYL)-6-CYCLOPENTYL-4-HYDROXY-6-[2-(4-HYDROXY-PHENYL)-ETHYL]-5,6-DIHYDRO-PYRAN-2-ONE	non-polymer		495.7	1	Chemie (NH1)
3		water	water		18.0	560	Chemie (HOH)

Sequence modifications

A: 1 - 571 (UniProt: P26663)

PDB	External Database	Details
Gln 47	Leu 2466	engineered mutation
Tyr 101	Phe 2520	engineered mutation
Arg 114	Lys 2533	engineered mutation
His 572	-	expression tag
His 573	-	expression tag
His 574	-	expression tag
His 575	-	expression tag
His 576	-	expression tag
His 577	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	64162.5
Non-Polymers*	Number of molecules	1
	Total formula weight	495.7
All*	Total formula weight	64658.1

*Water molecules are not included.