4A7B
MMP13 IN COMPLEX WITH A NOVEL SELECTIVE NON ZINC BINDING INHIBITOR CMPD22
Summary for 4A7B
Entry DOI | 10.2210/pdb4a7b/pdb |
Related | 1EUB 1FLS 1FM1 1PEX 1UC1 1XUC 1XUD 1XUR 1YOU 1ZTQ 2D1N 2YIG 3ZXH 456C 830C |
Descriptor | COLLAGENASE 3, N-[(3S)-1,1-dioxidotetrahydro-2H-thiopyran-3-yl]-4-(4-{[(3S)-3-hydroxy-1-azabicyclo[2.2.2]oct-3-yl]ethynyl}phenoxy)benzamide, ACETOHYDROXAMIC ACID, ... (9 entities in total) |
Functional Keywords | hydrolase |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Secreted, extracellular space, extracellular matrix : P45452 |
Total number of polymer chains | 2 |
Total formula weight | 39839.79 |
Authors | Hargreaves, D.,Gerhardt, S. (deposition date: 2011-11-11, release date: 2011-12-21, Last modification date: 2024-05-08) |
Primary citation | De Savi, C.,Morley, A.D.,Nash, I.,Karoutchi, G.,Page, K.,Ting, A.,Gerhardt, S. Lead Optimisation of Selective Non-Zinc Binding Inhibitors of Mmp13. Part 2. Bioorg.Med.Chem.Lett., 22:271-, 2012 Cited by PubMed: 22153941DOI: 10.1016/J.BMCL.2011.11.034 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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