2YIG

MMP13 in complex with a novel selective non zinc binding inhibitor

Summary for 2YIG

• Entry DOI: 10.2210/pdb2yig/pdb
• Related: 1EUB 1FLS 1FM1 1PEX 1UC1 1XUC 1XUD 1XUR 1YOU 1ZTQ 2D1N 456C 830C
• Descriptor: COLLAGENASE 3, 4-(4-{[(3S)-3-HYDROXY-1-AZABICYCLO[2.2.2]OCT-3-YL]ETHYNYL}PHENOXY)-N-(PYRIDIN-4-YLMETHYL)BENZAMIDE, ZINC ION, ... (6 entities in total)
• Functional Keywords: hydrolase, collagenase 3, mmp-13, matrixmetalloprotease
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Secreted, extracellular space, extracellular matrix : P45452
• Total number of polymer chains: 2
• Total formula weight: 39868.75

Authors

Gerhardt, S.,Hargreaves, D. (deposition date: 2011-05-13, release date: 2011-06-29, Last modification date: 2017-07-12)

• Primary citation: Savi, C.D.,Morley, A.D.,Ting, A.,Nash, I.,Karabelas, K.,Wood, C.M.,James, M.,Norris, S.J.,Karoutchi, G.,Rankine, N.,Hamlin, G.,Macfaul, P.A.,Ryan, D.,Baker, S.V.,Hargreaves, D.,Gerhardt, S.; Selective Non Zinc Binding Inhibitors of Mmp13.; Bioorg.Med.Chem.Lett., 21:4215-, 2011; PubMed: 21669521; DOI: 10.1016/J.BMCL.2011.05.075

Experimental method

X-RAY DIFFRACTION (1.7 Å)