1YOU
Crystal structure of the catalytic domain of MMP-13 complexed with a potent pyrimidinetrione inhibitor
Summary for 1YOU
Entry DOI | 10.2210/pdb1you/pdb |
Descriptor | Collagenase 3, ZINC ION, CALCIUM ION, ... (6 entities in total) |
Functional Keywords | hydrolase, metalloprotease |
Biological source | Homo sapiens (human) |
Cellular location | Secreted, extracellular space, extracellular matrix (Probable): P45452 |
Total number of polymer chains | 2 |
Total formula weight | 39252.88 |
Authors | Pandit, J. (deposition date: 2005-01-28, release date: 2005-03-15, Last modification date: 2023-08-23) |
Primary citation | Blagg, J.A.,Noe, M.C.,Wolf-Gouveia, L.A.,Reiter, L.A.,Laird, E.R.,Chang, S.P.,Danley, D.E.,Downs, J.T.,Elliott, N.C.,Eskra, J.D.,Griffiths, R.J.,Hardink, J.R.,Haugeto, A.I.,Jones, C.S.,Liras, J.L.,Lopresti-Morrow, L.L.,Mitchell, P.G.,Pandit, J.,Robinson, R.P.,Subramanyam, C.,Vaughn-Bowser, M.L.,Yocum, S.A. Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14. Bioorg.Med.Chem.Lett., 15:1807-1810, 2005 Cited by PubMed: 15780611DOI: 10.1016/j.bmcl.2005.02.038 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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