3ZXH

MMP-13 complexed with 2-Napthylsulfonamide hydroxamic acid inhibitor

Summary for 3ZXH

Entry DOI	10.2210/pdb3zxh/pdb
Related	1EUB 1FLS 1FM1 1PEX 1UC1 1XUC 1XUD 1XUR 1YOU 1ZTQ 2D1N 2YIG 456C 830C
Descriptor	COLLAGENASE 3, ZINC ION, CALCIUM ION, ... (6 entities in total)
Functional Keywords	metallo-enzyme, carboxylate inhibitor, collagen degradation, extracellular matrix, hydrolase, metal-binding, metalloprotease
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	2
Total formula weight	40258.44
Authors	Clark, K.L.,Kulathila, R. (deposition date: 2011-08-10, release date: 2011-10-19, Last modification date: 2019-04-03)
Primary citation	Tommasi, R.A.,Weiler, S.,Mcquire, L.W.,Rogel, O.,Chambers, M.,Clark, K.L.,Doughty, J.,Fang, J.,Ganu, V.,Grob, J.,Goldberg, R.,Goldstein, R.,Lavoie, S.,Kulathila, R.,Macchia, W.,Melton, R.,Springer, C.,Walker, M.,Zhang, J.,Zhu, L.,Shultz, M. Potent and Selective 2-Naphthylsulfonamide Substituted Hydroxamic Acid Inhibitors of Matrix Metalloproteinase-13. Bioorg.Med.Chem.Lett., 21:6440-, 2011 Cited by PubMed: 21937229 DOI: 10.1016/J.BMCL.2011.08.087 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation