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4A30

CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND

Summary for 4A30
Entry DOI10.2210/pdb4a30/pdb
Related2WSA 4A2Z 4A31 4A32 4A33
DescriptorGLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, CHLORIDE ION, GLYCEROL, ... (6 entities in total)
Functional Keywordsacyltransferase, transferase, drug discovery
Biological sourceLEISHMANIA MAJOR
Total number of polymer chains1
Total formula weight52031.81
Authors
Robinson, D.A.,Brand, S.,Fairlamb, A.H.,Ferguson, M.A.J.,Frearson, J.A.,Wyatt, P.G. (deposition date: 2011-09-29, release date: 2011-12-21, Last modification date: 2023-12-20)
Primary citationBrand, S.,Cleghorn, L.A.,McElroy, S.P.,Robinson, D.A.,Smith, V.C.,Hallyburton, I.,Harrison, J.R.,Norcross, N.R.,Spinks, D.,Bayliss, T.,Norval, S.,Stojanovski, L.,Torrie, L.S.,Frearson, J.A.,Brenk, R.,Fairlamb, A.H.,Ferguson, M.A.,Read, K.D.,Wyatt, P.G.,Gilbert, I.H.
Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors.
J. Med. Chem., 55:140-152, 2012
Cited by
PubMed: 22148754
DOI: 10.1021/jm201091t
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.5 Å)
Structure validation

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