4A30
CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE | polymer | 438 | 50513.3 | 1 | UniProt (Q4Q5S8) Pfam (PF01233) Pfam (PF02799) | LEISHMANIA MAJOR | N-MYRISTOYL TRANSFERASE |
| 2 | B (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 3 | C (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | D (A) | 4-BROMO-2,6-DICHLORO-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE | non-polymer | 413.1 | 1 | Chemie (QMI) | |||
| 5 | E (A) | TETRADECANOYL-COA | non-polymer | 977.9 | 1 | Chemie (MYA) | |||
| 6 | F (A) | water | water | 18.0 | 275 | Chemie (HOH) |
Sequence modifications
A: 5 - 421 (UniProt: Q4Q5S8)
| PDB | External Database | Details |
|---|---|---|
| Met -16 | - | expression tag |
| Gly -15 | - | expression tag |
| Ser -14 | - | expression tag |
| Ser -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| Ser -6 | - | expression tag |
| Ser -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Arg -3 | - | expression tag |
| Glu -2 | - | expression tag |
| Asn -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Tyr 1 | - | expression tag |
| Phe 2 | - | expression tag |
| Gln 3 | - | expression tag |
| Gly 4 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 50513.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1518.6 | |
| All* | Total formula weight | 52031.8 |
