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4A32

CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND

Summary for 4A32
Entry DOI10.2210/pdb4a32/pdb
Related2WSA 4A2Z 4A30 4A31 4A33
DescriptorGLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, GLYCEROL, 3,5-DICHLORO-3'-[(DIETHYLAMINO)METHYL]-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BIPHENYL-4-SULFONAMIDE, ... (5 entities in total)
Functional Keywordsacyltransferase, transferase, drug discovery, leishmaniasis
Biological sourceLEISHMANIA MAJOR
Total number of polymer chains1
Total formula weight52078.70
Authors
Primary citationBrand, S.,Cleghorn, L.A.,McElroy, S.P.,Robinson, D.A.,Smith, V.C.,Hallyburton, I.,Harrison, J.R.,Norcross, N.R.,Spinks, D.,Bayliss, T.,Norval, S.,Stojanovski, L.,Torrie, L.S.,Frearson, J.A.,Brenk, R.,Fairlamb, A.H.,Ferguson, M.A.,Read, K.D.,Wyatt, P.G.,Gilbert, I.H.
Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors.
J. Med. Chem., 55:140-152, 2012
Cited by
PubMed: 22148754
DOI: 10.1021/jm201091t
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

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