Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4A33

CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND

Summary for 4A33
Entry DOI10.2210/pdb4a33/pdb
Related2WSA 4A2Z 4A30 4A31 4A32
DescriptorGLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, 2,6-DICHLORO-4-(6-PIPERAZIN-1-YLPYRIDIN-3-YL)-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE, TETRADECANOYL-COA, ... (4 entities in total)
Functional Keywordstransferase, drug discovery
Biological sourceLEISHMANIA MAJOR
Total number of polymer chains1
Total formula weight51986.57
Authors
Primary citationBrand, S.,Cleghorn, L.A.,McElroy, S.P.,Robinson, D.A.,Smith, V.C.,Hallyburton, I.,Harrison, J.R.,Norcross, N.R.,Spinks, D.,Bayliss, T.,Norval, S.,Stojanovski, L.,Torrie, L.S.,Frearson, J.A.,Brenk, R.,Fairlamb, A.H.,Ferguson, M.A.,Read, K.D.,Wyatt, P.G.,Gilbert, I.H.
Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors.
J. Med. Chem., 55:140-152, 2012
Cited by
PubMed: 22148754
DOI: 10.1021/jm201091t
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

217157

PDB entries from 2024-03-13

PDB statisticsPDBj update infoContact PDBjnumon