Summary for 4A1Z

Related2FKY 2X7C 2XAE 1Q0B 2X2R 2FL6 2UYM 2X7D 2X7E 1II6 2UYI 2WOG 2G1Q 1YRS 2GM1 1X88 2FL2
DescriptorKINESIN-LIKE PROTEIN KIF11, MAGNESIUM ION, NITRATE ION, ... (5 entities in total)
Functional Keywordsmotor protein
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCytoplasm P52732
Total number of polymer chains2
Total molecular weight83106.27
Talapatra, S.K.,Kozielski, F. (deposition date: 2011-09-20, release date: 2012-10-31, Last modification date: 2013-09-04)
Primary citation
Talapatra, S.K.,Anthony, N.G.,Mackay, S.P.,Kozielski, F.
The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism.
J.Med.Chem., 56:6317-, 2013
PubMed: 23875972 (PDB entries with the same primary citation)
DOI: 10.1021/JM4006274
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.249170.3%9.7%2.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution