4XPT
X-ray structure of Drosophila dopamine transporter with subsiteB mutations D121G/S426M and EL2 deletion of 162-201 in complex with substrate analogue 3,4 dichlorophen ethylamine
Summary for 4XPT
| Entry DOI | 10.2210/pdb4xpt/pdb |
| Related | 4M48 4XNU 4XNX 4XP1 4XP4 4XP5 4XP6 4XP9 4XPA 4XPB 4XPF 4XPG 4XPH |
| Related PRD ID | PRD_900018 |
| Descriptor | Dopamine transporter, SODIUM ION, antibody fragment light chain, ... (10 entities in total) |
| Functional Keywords | integral membrane protein, all-alpha helical antidepressant complex, transport protein-inhibitor complex, protein transport-inhibitor complex, protein transport/inhibitor |
| Biological source | Drosophila melanogaster (Fruit fly) More |
| Total number of polymer chains | 3 |
| Total formula weight | 109981.09 |
| Authors | Aravind, P.,Wang, K.,Gouaux, E. (deposition date: 2015-01-17, release date: 2015-05-06, Last modification date: 2023-09-27) |
| Primary citation | Wang, K.H.,Penmatsa, A.,Gouaux, E. Neurotransmitter and psychostimulant recognition by the dopamine transporter. Nature, 521:322-327, 2015 Cited by PubMed: 25970245DOI: 10.1038/nature14431 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.36 Å) |
Structure validation
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