4KSH
Dna gyrase atp binding domain of enterococcus faecalis in complex with a small molecule inhibitor (7-({4-[(3R)-3-AMINOPYRROLIDIN-1-YL]-5-CHLORO-6-ETHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-2-YL}SULFANYL)-1,5-NAPHTHYRIDIN-1(4H)-OL)
Summary for 4KSH
Entry DOI | 10.2210/pdb4ksh/pdb |
Related | 4GEE 4K4O 4KFG 4KSG 4KTN |
Descriptor | DNA gyrase subunit B, 7-({4-[(3R)-3-aminopyrrolidin-1-yl]-5-chloro-6-ethyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl}sulfanyl)-1,5-naphthyridin-1(4H)-ol, GLYCEROL, ... (4 entities in total) |
Functional Keywords | atp-binding, nucleotide-binding, topoisomerase, atp-binding domain, dna gyrase negatively supercoils closed circular double-stranded dna in an atp-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded dna rings, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor |
Biological source | Enterococcus faecalis |
Cellular location | Cytoplasm (By similarity): Q839Z1 |
Total number of polymer chains | 1 |
Total formula weight | 24371.66 |
Authors | Bensen, D.C.,Akers-Rodriguez, S.,Tari, L.W. (deposition date: 2013-05-17, release date: 2014-01-15, Last modification date: 2024-02-28) |
Primary citation | Tari, L.W.,Bensen, D.C.,Finn, J. A new class of type iia topoisomerase inhibitors with broad-spectrum antibacterial activity To be Published, |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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