4KSH

Dna gyrase atp binding domain of enterococcus faecalis in complex with a small molecule inhibitor (7-({4-[(3R)-3-AMINOPYRROLIDIN-1-YL]-5-CHLORO-6-ETHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-2-YL}SULFANYL)-1,5-NAPHTHYRIDIN-1(4H)-OL)

Summary for 4KSH

• Entry DOI: 10.2210/pdb4ksh/pdb
• Related: 4GEE 4K4O 4KFG 4KSG 4KTN
• Descriptor: DNA gyrase subunit B, 7-({4-[(3R)-3-aminopyrrolidin-1-yl]-5-chloro-6-ethyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl}sulfanyl)-1,5-naphthyridin-1(4H)-ol, GLYCEROL, ... (4 entities in total)
• Functional Keywords: atp-binding, nucleotide-binding, topoisomerase, atp-binding domain, dna gyrase negatively supercoils closed circular double-stranded dna in an atp-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded dna rings, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor
• Biological source: Enterococcus faecalis
• Cellular location: Cytoplasm (By similarity): Q839Z1
• Total number of polymer chains: 1
• Total formula weight: 24371.66

Authors

Bensen, D.C.,Akers-Rodriguez, S.,Tari, L.W. (deposition date: 2013-05-17, release date: 2014-01-15, Last modification date: 2024-02-28)

• Primary citation: Tari, L.W.,Bensen, D.C.,Finn, J.; A new class of type iia topoisomerase inhibitors with broad-spectrum antibacterial activity; To be Published,

Experimental method

X-RAY DIFFRACTION (1.7 Å)